Spain launches MamoRisk to personalize breast cancer risk prediction

Spain has launched MamoRisk, a pioneering study to develop a personalized breast cancer risk calculator that incorporates genetic, lifestyle, and mammographic data. The project involves 10,000 women from 14 autonomous communities and aims to tailor screening programs based on individual risk levels.

How it works

MamoRisk uses the BOADICEA algorithm, which combines information on genetic variants (including high-risk BRCA1/BRCA2 genes), family history, lifestyle factors, and mammographic density. Participants provide a saliva sample for genetic analysis and share clinical data. The model classifies women into low, intermediate, or high risk for developing breast cancer within two and five years Source: El Mundo.

• The study is led by the IDIS, CNIO, and IISGS institutes, with €1.2 million in funding from the Spanish Ministry of Science through the Instituto de Salud Carlos III Source: Infobae.
• It begins in Galicia, where women diagnosed with breast cancer and healthy women are being invited to participate Source: El Confidencial.

The study design

A total of 10,000 women will be enrolled: 4,000 diagnosed with breast cancer and 6,000 healthy controls, randomly selected from screening programs with at least six years of follow-up. The model's predictions will be compared against actual outcomes to validate its accuracy Source: Infobae.

Implications for screening

If validated, the tool could replace the current one-size-fits-all screening approach. Women at higher risk would receive more intensive monitoring or preventive measures, while those at lower risk might be screened less frequently, optimizing resources and improving early detection . The project also integrates artificial intelligence for mammographic analysis and is supported by 14 autonomous communities .