The LatAm-FINGERS study, the first randomized multicenter trial in Latin America on cognitive decline prevention, found that a multi-domain lifestyle intervention led to 55% greater cognitive improvements compared to general health advice in older adults at risk of dementia. The results were published in The Lancet and presented at the Alzheimer's Association International Conference 2026 in London.
Over two years, 1,065 participants aged 60–77 from 11 countries (Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Ecuador, Mexico, Peru, Dominican Republic, and Uruguay) followed a structured protocol. The intervention group showed significant gains in global cognition, episodic memory, attention, and executive functions Source: Infobae. The study's completion rate was 82.3% Source: Excelsior MX.
The intervention combined:
These were implemented simultaneously and adapted to Latin American realities Source: El Colombiano.
“LatAm-FINGERS demonstrates that prevention of cognitive decline in Latin America is not only possible but can be built on evidence generated in our own region,” said Dr. Lucía Crivelli, lead investigator and neuropsychologist at FLENI, Argentina. The study highlights that up to 54% of dementia cases in the region could be prevented by addressing modifiable risk factors Source: Infobae opinion. Researchers caution the findings do not guarantee individual protection but provide robust evidence for public health strategies Source: Emol.
“demostró que intervenir de manera combinada y sostenida sobre cinco factores modificables del estilo de vida, puede mejorar la cognición global en adultos mayores en riesgo de demencia.”
“El 82,3% de los participantes completó los dos años de seguimiento.”
“La investigación fue financiada por la Alzheimer’s Association y se llevó a cabo en el marco de la iniciativa Latam Fingers, una red integrada por equipos científicos.”
“el grupo que recibió la intervención multidominio estructurada 'obtuvo mejoras cognitivas un 55% superiores a las del grupo que recibió una intervención flexible basada en consejos regulares de salud'.”
“En América Latina, un estudio reciente estimó que alrededor del 54% de los casos de demencia podrían evitarse si redujéramos estos factores de riesgo potencialmente modificables.”